KMID : 0363320110320040542
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Journal of Korean Oriental Internal Medicine 2011 Volume.32 No. 4 p.542 ~ p.549
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Effect of Saengmaeg-san Extract on Xerostomia in Stroke Patients : A Double-Blind Randomized Controlled Study
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Lee Dae-Hyun
Han Hyun-Jin Kim Lak-Hyung Kang Sei-Young Jang In-San
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Abstract
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Objectives: The present study was made to evaluate the clinical effectiveness of Saengmaeg-san (ßæØæߤ) extract to treat xerostomia in stroke patients.
Methods: The study design was a double-blind randomized controlled trial. Subjects were stroke patients with xerostomia. They were allocated to either the Saengmaeg-san (n=12) or placebo group (n=12). Saengmaeg-san extract or a placebo in similar opaque capsules was given three times a day for a week. The improvement of xerostomia was measured by the xerostomia-evaluating questionnaire, developed by the school of dentistry in Seoul National University, before baseline and one week later. Eleven of the Saengmaeg-san group and ten of the placebo group finished the trial and were analyzed. Paired samples t-test and Mann-Whitney test were applied to statistical analysis.
Results: On three of the six questions, the Saengmaeg-san group improved significantly. On two of the six questions, the Saengmaeg-san group improved significantly more than the placebo group. On the other questions, the Saengmaeg-san group improved more than the placebo group, although significance was not reached.
Conclusion: These results demonstrate that Saengmaeg-san extract is effective for treating xerostomia in stroke patients, and further studies should be conducted to provide more valuable information.
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KEYWORD
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xerostomia, Saengmaeg-san, stroke, dry mouth, Korean medicine
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